---
name: Autonomous Oncology Agent
slug: autonomous-oncology-agent
category: AI Engineering
description: Autonomous Oncology Agent combines LLM reasoning with vision transformer analysis of H&E slides to predict biomarkers, retrieve evidence, and generate ranked treatment options. Use it for tumor board style precision oncology decision support.
github: "https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/autonomous-oncology-agent"
language: Python
stars: 2944
forks: 410
install: "npx degit https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/autonomous-oncology-agent ~/.claude/skills/autonomous-oncology-agent"
installs_to: ~/.claude/skills/autonomous-oncology-agent
source_path: skills/autonomous-oncology-agent/SKILL.md
collection_size: 25
category_size: 2451
collection_url: "https://dirskills.com/collections/FreedomIntelligence/OpenClaw-Medical-Skills"
added: 2026-08-17T07:09:41.264Z
last_synced: 2026-08-17T07:09:41.264Z
canonical_url: "https://dirskills.com/skills/autonomous-oncology-agent"
---

# Autonomous Oncology Agent

Autonomous Oncology Agent combines LLM reasoning with vision transformer analysis of H&E slides to predict biomarkers, retrieve evidence, and generate ranked treatment options. Use it for tumor board style precision oncology decision support.

**Install:**

```bash
npx degit https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/autonomous-oncology-agent ~/.claude/skills/autonomous-oncology-agent
```

## README

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# COPYRIGHT NOTICE
# This file is part of the "Universal Biomedical Skills" project.
# Copyright (c) 2026 MD BABU MIA, PhD <md.babu.mia@mssm.edu>
# All Rights Reserved.
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# This code is proprietary and confidential.
# Unauthorized copying of this file, via any medium is strictly prohibited.
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---
name: autonomous-oncology-agent
description: Precision Oncology
keywords:
  - oncology
  - multimodal
  - H&E
  - biomarkers
  - NCCN
measurable_outcome: Generate a prioritized treatment plan with evidence levels and predicted biomarker status (MSI/KRAS) within 5 minutes of data ingest.
license: MIT
metadata:
  author: Nature Cancer 2025
  version: "1.0.0"
compatibility:
  - system: Python 3.9+
allowed-tools:
  - run_shell_command
  - web_fetch
---

# Autonomous Clinical AI Agent (Oncology)

This skill implements the capabilities of the "Autonomous Clinical AI Agent" described in Nature Cancer (2025). It combines Large Language Models (LLMs) for reasoning with specialized vision models for pathology image analysis to support precision oncology decision-making.

## When to Use This Skill

*   **Precision Oncology**: For interpreting complex cancer cases involving pathology, genomics, and clinical history.
*   **Biomarker Detection**: To identify status of key biomarkers (MSI, KRAS, BRAF) from pathology slides (H&E).
*   **Guideline Adherence**: To check treatment plans against NCCN or ASCO guidelines (via OncoKB/PubMed).
*   **Multimodal Synthesis**: When you need to combine image data and text reports.

## Core Capabilities

1.  **Vision Transformer Analysis**: Detects MSI status and key mutations (KRAS, BRAF) directly from H&E images.
2.  **Clinical Reasoning**: Synthesizes patient history, pathology, and genomics to recommend therapies.
3.  **Evidence Retrieval**: Integrates real-time knowledge from OncoKB and PubMed.
4.  **Decision Support**: Provides ranked treatment options with evidence levels.

## Workflow

1.  **Input Processing**:
    *   Text: Clinical notes, pathology reports, genomic panels.
    *   Image: H&E histology slides.
2.  **Analysis**:
    *   Vision model predicts molecular features from slides.
    *   LLM extracts key clinical entities (Stage, Histology, Mutations).
3.  **Reasoning**:
    *   Query OncoKB for actionable mutations.
    *   Match against standard of care guidelines.
4.  **Output**: Generate a comprehensive "Tumor Board" style report.

## Example Usage

**User**: "Review this case of metastatic colorectal cancer. The H&E slide is attached. What is the predicted MSI status and recommended first-line therapy?"

**Agent Action**:
1.  Runs vision model on H&E image -> Output: "MSI-High (Predicted)".
2.  Reads clinical notes -> "Patient is fit, ECOG 0."
3.  Consults Knowledge Base -> "MSI-High CRC responds to Pembrolizumab."
4.  Recommends: "Based on predicted MSI-High status, immunotherapy (Pembrolizumab) is recommended over standard chemotherapy..."


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