Binder Design

by FreedomIntelligence

Binder Design is an AI Engineering skill for Claude Code, published by FreedomIntelligence in OpenClaw-Medical-Skills.

2.9K stars410 forkson FreedomIntelligence/OpenClaw-Medical-SkillsAdded 2026/08/17Repository updated 2026/07/21

View source on GitHub Download repo ZIP

awesomeclaude-codeclawhubmedicalnanoclawopenclawopenclaw-skillsskills

Install in seconds

Install Binder Design

Copy Binder Design into your Claude Code skills folder. Run the command in your terminal, or review the source on GitHub before installing.

terminal

npx degit https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/binder-design ~/.claude/skills/binder-design

Requires Node.js. Downloads this skill only — not the rest of the repository — into your Claude Code skills folder.

Without Node.js

git clone https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git

Clones the whole repository, then copy the skill’s own directory into your skills folder yourself.

In this catalog

Source file: skills/binder-design/SKILL.md in FreedomIntelligence/OpenClaw-Medical-Skills
Installs to: ~/.claude/skills/binder-design
Collection: One of 25 skills cataloged from this repository
Category: AI Engineering — 2451 skills

What Binder Design does

Binder Design helps choose between BoltzGen, BindCraft, RFdiffusion, and Germinal for de novo protein binder design, then guides target preparation, hotspot selection, generation, and filtering with validation metrics.

Binder Design is cataloged under AI Engineering on DirSkills. Binder Design comes from a repository tagged awesome, claude-code, clawhub, medical and nanoclaw.

Documentation

README

Excerpt

Binder Design Tool Selection

Decision tree

De novo binder design?
│
├─ Standard target → BoltzGen (recommended)
│   All-atom output (no separate ProteinMPNN step needed)
│   Better for ligand/small molecule binding
│   Single-step design (backbone + sequence + side chains)
│
├─ Need diversity/exploration → RFdiffusion + ProteinMPNN
│   Maximum backbone diversity
│   Two-step: backbone then sequence
│
├─ Integrated validation → BindCraft
│   Built-in AF2 validation
│   End-to-end pipeline
│
├─ Ligand binding → BoltzGen ✓
│   All-atom diffusion handles ligand context
│
├─ Peptide/nanobody → Germinal
│   VHH/nanobody design
│   Germline-aware optimization
│
└─ Antibody/Nanobody
    +-- VHH design --> germinal skill

Tool comparison

This is the opening of the README. Read the full README on GitHub.

Frequently asked about Binder Design

What else does FreedomIntelligence publish alongside Binder Design?
Binder Design is one of 25 skills that DirSkills catalogs from FreedomIntelligence/OpenClaw-Medical-Skills, the repository it ships in. Its siblings there include AAV Vector Design Agent, ADHD Daily Planner and ADMET Prediction. Each one is a separate skill with its own page in this directory, installs the same way Binder Design does, and is maintained by FreedomIntelligence in that same repository. The rest of the collection is listed on the FreedomIntelligence/OpenClaw-Medical-Skills page.
How does Binder Design compare to other AI Engineering skills?
Binder Design ranks #696 by stars among the 2451 AI Engineering skills in this catalog. The most-starred ones next to it are Architecture Decision Records, AI-First Engineering and Agentic OS. DirSkills ranks by the star count of the repository each skill ships in, so that order reflects how popular those repositories are rather than any review of Binder Design against them. Open each page to compare what they document and how they install.