ESM2

ESM2 is an AI Engineering skill for Claude Code, published by BioTender-max in awesome-bio-agent-skills.

174 stars30 forkson BioTender-max/awesome-bio-agent-skillsAdded 2026/09/07+1% in starsRepository updated 2026/07/01

agent-skillsai-agentai-agentsawesomeawesome-listbioinformaticsbiomedicalclaudeclaude-codeclaude-skillscomputational-biologydrug-discoverygenomicsllmmcpprotein-designproteomicssingle-cellskillstranscriptomics

Install in seconds

Install ESM2

Copy ESM2 into your Claude Code skills folder. Run the command in your terminal, or review the source on GitHub before installing.

terminal

npx degit https://github.com/BioTender-max/awesome-bio-agent-skills/tree/main/skills/adaptyv/esm ~/.claude/skills/esm

Requires Node.js. Downloads this skill only — not the rest of the repository — into your Claude Code skills folder.

Without Node.js

git clone https://github.com/BioTender-max/awesome-bio-agent-skills.git

Clones the whole repository, then copy the skill’s own directory into your skills folder yourself.

In this catalog

Source file: skills/adaptyv/esm/SKILL.md in BioTender-max/awesome-bio-agent-skills
Installs to: ~/.claude/skills/esm
Collection: One of 25 skills cataloged from this repository
Category: AI Engineering — 3475 skills

What ESM2 does

ESM2 produces protein embeddings and pseudo-log-likelihood scores for sequence plausibility. Use it for clustering, variant effect prediction, and filtering designed sequences before downstream analysis.

ESM2 is cataloged under AI Engineering on DirSkills. ESM2 comes from a repository tagged agent-skills, ai-agent, ai-agents, awesome and awesome-list.

Documentation

README

Excerpt

ESM2 Protein Language Model

Prerequisites

Requirement	Minimum	Recommended
Python	3.8+	3.10
PyTorch	1.10+	2.0+
CUDA	11.0+	11.7+
GPU VRAM	8GB	24GB (A10G)
RAM	16GB	32GB

How to run

First time? See Installation Guide to set up Modal and biomodals.

cd biomodals
modal run modal_esm2_predict_masked.py \
  --input-faa sequences.fasta \
  --out-dir embeddings/

GPU: A10G (24GB) | Timeout: 300s default

This is the opening of the README. Read the full README on GitHub.

Frequently asked about ESM2

What else does BioTender-max publish alongside ESM2?
ESM2 is one of 25 skills that DirSkills catalogs from BioTender-max/awesome-bio-agent-skills, the repository it ships in. Its siblings there include ATAC Seq, AlphaFold and BindCraft Binder Design. Each one is a separate skill with its own page in this directory, installs the same way ESM2 does, and is maintained by BioTender-max in that same repository. The rest of the collection is listed on the BioTender-max/awesome-bio-agent-skills page.
How does ESM2 compare to other AI Engineering skills?
ESM2 ranks #3215 by stars among the 3475 AI Engineering skills in this catalog. The most-starred ones next to it are Architecture Decision Records, AI-First Engineering and Agentic OS. DirSkills ranks by the star count of the repository each skill ships in, so that order reflects how popular those repositories are rather than any review of ESM2 against them. Open each page to compare what they document and how they install.