SolubleMPNN

SolubleMPNN is an AI Engineering skill for Claude Code, published by BioTender-max in awesome-bio-agent-skills.

174 stars30 forkson BioTender-max/awesome-bio-agent-skillsAdded 2026/09/07+1% in starsRepository updated 2026/07/01

agent-skillsai-agentai-agentsawesomeawesome-listbioinformaticsbiomedicalclaudeclaude-codeclaude-skillscomputational-biologydrug-discoverygenomicsllmmcpprotein-designproteomicssingle-cellskillstranscriptomics

Install in seconds

Install SolubleMPNN

Copy SolubleMPNN into your Claude Code skills folder. Run the command in your terminal, or review the source on GitHub before installing.

terminal

npx degit https://github.com/BioTender-max/awesome-bio-agent-skills/tree/main/skills/adaptyv/solublempnn ~/.claude/skills/solublempnn

Requires Node.js. Downloads this skill only — not the rest of the repository — into your Claude Code skills folder.

Without Node.js

git clone https://github.com/BioTender-max/awesome-bio-agent-skills.git

Clones the whole repository, then copy the skill’s own directory into your skills folder yourself.

In this catalog

Source file: skills/adaptyv/solublempnn/SKILL.md in BioTender-max/awesome-bio-agent-skills
Installs to: ~/.claude/skills/solublempnn
Collection: One of 25 skills cataloged from this repository
Category: AI Engineering — 3475 skills

What SolubleMPNN does

SolubleMPNN designs protein sequences with a soluble model variant for E. coli expression and higher solubility. Use it to reduce aggregation or inclusion bodies when standard ProteinMPNN is too hydrophobic.

SolubleMPNN is cataloged under AI Engineering on DirSkills. SolubleMPNN comes from a repository tagged agent-skills, ai-agent, ai-agents, awesome and awesome-list.

Documentation

README

Excerpt

SolubleMPNN Solubility-Optimized Design

Prerequisites

Requirement	Minimum	Recommended
Python	3.8+	3.10
CUDA	11.0+	11.7+
GPU VRAM	8GB	16GB (T4)
RAM	8GB	16GB

How to run

First time? See Installation Guide to set up Modal and biomodals.

SolubleMPNN uses the ProteinMPNN Modal wrapper with soluble model:

cd biomodals
modal run modal_proteinmpnn.py \
  --pdb-path backbone.pdb \
  --num-seq-per-target 16 \
  --sampling-temp 0.1 \
  --model-name v_48_020

GPU: T4 (16GB) | Timeout: 600s default

This is the opening of the README. Read the full README on GitHub.

Frequently asked about SolubleMPNN

What else does BioTender-max publish alongside SolubleMPNN?
SolubleMPNN is one of 25 skills that DirSkills catalogs from BioTender-max/awesome-bio-agent-skills, the repository it ships in. Its siblings there include ATAC Seq, AlphaFold and BindCraft Binder Design. Each one is a separate skill with its own page in this directory, installs the same way SolubleMPNN does, and is maintained by BioTender-max in that same repository. The rest of the collection is listed on the BioTender-max/awesome-bio-agent-skills page.
How does SolubleMPNN compare to other AI Engineering skills?
SolubleMPNN ranks #3240 by stars among the 3475 AI Engineering skills in this catalog. The most-starred ones next to it are Architecture Decision Records, AI-First Engineering and Agentic OS. DirSkills ranks by the star count of the repository each skill ships in, so that order reflects how popular those repositories are rather than any review of SolubleMPNN against them. Open each page to compare what they document and how they install.